The mechanisms by which sex is genetically determined are bewilderingly diverse and appear to change rapidly during evolution.(1) What makes the sex‐determining process so prone to perturbations? Two recent articles(2,3) explore theoretically the role of genetic conflict in sex determination evolution. Both studies use the idea that selection on sex‐determining genes may act differently in parents and in offspring and they suggest that the resulting conflict can drive changes in sex‐determining mechanisms. BioEssays 23:477–480, 2001. © 2001 John Wiley & Sons, (...) Inc. (shrink)

Endosymbiotic bacteria can directly manipulate their host's sex determination towards the production of female offspring.

Sex‐determining mechanisms appear to be very diverse in invertebrates. Haplodiploidy is a widespread mode of reproduction in insects: males are haploid and females are diploid. Several models have been proposed for the genetic mechanisms of sex determination in haplodiploid Hymenoptera. Although a one‐locus multi‐allele model is valid for several species, sex determination in other species cannot be explained by any of the existing models. Evidence for and predictions of two recently proposed models are discussed. Some genetic and molecular approaches are (...) proposed to study sex determination in Hymenoptera. (shrink)

This dissertation is a defense of moderate invariantism, the traditional epistemological position combining the following three theses: invariantism, according to which the word ‘know’ expresses the same content in every context of use; intellectualism, according to which whether one knows a certain proposition does not depend on one’s practical interests; and antiskepticism, according to which we really do know much of what we ordinarily take ourselves to know. Moderate invariantism needs defending because of seemingly powerful arguments for contextualism, the view (...) that, like ‘I’ and ‘now’, ‘know’ expresses different contents in different contexts. It has been argued that only contextualism can properly reply to skeptical arguments, and that only contextualism can account for our tendency to go from judging that a knowledge claim is true to judging that it is false in response to shifts in the context of use. Moderate invariantist replies to these arguments have largely failed. I propose new replies on behalf of moderate invariantism, while critiquing earlier, less successful attempts. Chapter one is introductory. In chapters two and three, I examine contextualist replies to skeptical arguments arising from radical skeptical hypotheses (such as the possibility that one is a brain in a vat) and from considerations involving lotteries. I argue that if contextualism can adequately respond to these arguments, then there are equally effective replies available to the moderate invariantist. In the next two chapters, I examine Stewart Cohen’s “Airport Case,” which elicits intuitions about knowledge claims that supposedly only contextualism can accommodate. In chapter four, I argue that none of the invariantist replies to the case that depend on denying the intuitions succeed; in chapter five, I accept the intuitions, but argue that contextualism does not follow from them. Finally, in chapter six, I evaluate two interesting invariantist critiques of contextualism; according to the first, contextualism collapses into the radical position that every English expression is context-sensitive; according to the second, ‘know’ fails a test for context-sensitivity involving indirect speech reports. (shrink)

Now in its fifth edition, Good Reasoning Matters! is a practical guide to recognizing, evaluating, and constructing arguments. Combining straightforward instruction with abundant exercises and examples, this innovative introduction to argument schemes and rhetorical techniques will help students learn to think critically both within and beyond the classroom.

The Y chromosomes of most Drosophila species are necessary for male fertility but they are not involved in sex determination. They have many puzzling properties that resemble the effects caused by B chromosomes. Classical genetic and molecular studies reveal substantial affinities between Y and B chromosomes and suggest that the Y chromosomes of Drosophila are not degenerated homologues of the X chromosomes, but rather that their Y chromosomes evolved as specialized supernumeraries similar to classical B chromosomes.

On one hand, Chinese consumers are well known for conspicuous consumption and the adoption of luxury products and named brands. On the other hand, they also have a bad reputation for buying counterfeit products. Their simultaneous preferences for two contrasting types of product present a paradox that has not been addressed in the literature. This study attempts to present an explanation of this paradox by examining the effects of traditional Chinese cultural values and consumer values on consumers’ deontological judgment of (...) pirated CDs and the amount of social benefits they perceive they gain from them. We interviewed 300 Hong Kong Chinese consumers, and found that face consciousness increased materialism and risk aversion, thereby producing a favorable deontological judgment of pirated CDs. Face consciousness also has a direct effect on the amount of social benefits perceived in pirated CDs. Both favorable deontological judgment and perceived social benefits contributed to a strong intention to buy pirated CDs. The results are discussed in a cultural perspective. (shrink)

Carbon monoxide (CO), a product of organic oxidation processes, arises in vivo during cellular metabolism, most notably heme degradation. CO binds to the heme iron of most hemoproteins. Tissue hypoxia following hemoglobin saturation represents a principle cause of CO‐induced mortality in higher organisms, though cellular targets cannot be excluded. Despite extreme toxicity at high concentrations, low concentrations of CO can confer cytoprotection during ischemia/reperfusion or inflammation‐induced tissue injury. Likewise, heme oxygenase, an enzyme that produces CO, biliverdin and iron, as well (...) as a secondary increase in ferritin synthesis, from the oxidation of heme, can confer protection in vivo and in vitro. CO has been shown to affect several intracellular signaling pathways, including guanylate cyclase, which generates guanosine 3′:5′ cyclic monophosphate and the mitogen‐activated protein kinases (MAPK). Such pathways mediate, in part, the known vasoregulatory, anti‐inflammatory, anti‐apoptotic and anti‐proliferative effects of this gas. Exogenous CO delivered at low concentrations is showing therapeutic potential as an anti‐inflammatory agent and as such can modulate numerous pathophysiological states. This review will delve into the biological significance and medical applications of this gas molecule. BioEssays 26:270–280, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

I am in a difficult situation, being asked as a survivor to talk about people who are no longer with us, for survival always poses the problem of whether we have to deal with an event of a purely biological nature or one that, considered from an intellectual standpoint, is not merely arbitrary. Goethe frequently grappled with exactly this problem — if I may, for a moment, appeal to such a great standard. A second personal remark: when one has lived (...) as long as I have and belonged to a group that has gained such historical significance, one is constantly considered a kind of historical fragment. (shrink)

A set X of nonnegative integers is computably enumerable (c.e.), also called recursively enumerable (r.e.), if there is a computable method to list its elements. Let ε denote the structure of the computably enumerable sets under inclusion, $\varepsilon = (\{W_e\}_{e\in \omega}, \subseteq)$ . We previously exhibited a first order ε-definable property Q(X) such that Q(X) guarantees that X is not Turing complete (i.e., does not code complete information about c.e. sets). Here we show first that Q(X) implies that X has (...) a certain "slowness" property whereby the elements must enter X slowly (under a certain precise complexity measure of speed of computation) even though X may have high information content. Second we prove that every X with this slowness property is computable in some member of any nontrivial orbit, namely for any noncomputable A ∈ ε there exists B in the orbit of A such that X ≤ T B under relative Turing computability (≤ T ). We produce B using the Δ 0 3 -automorphism method we introduced earlier. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BUDDHISM AND MIMETIC THEORY: A RESPONSE TO CHRISTOPHER IVES Leo D. Lefebure Fordham University ChristopherIves offers avery clearandthoughtful exploration ofthe relation between Dharma and Destruction. His discussion helps us to understand the historical relation between institutions and violence in various Buddhist traditions. His overview of the historical record is quite compelling, offering us an important counterpoint and corrective to the widespread images of Buddhist peacemakers in the popular media. (...) From the beginning, the Buddhist tradition has had a mixed record in its understanding and practice of the first moral precept, nonviolence. The encounter between Buddhist perspectives and mimetic theory poses interesting challenges for both partners to the discussion. Mimetic theory offers Buddhists an analysis ofthe construction ofdesire and the self that in many ways complements traditional Buddhist perspectives. It also offers a naming ofthe mechanisms of violence in the formation of societies that may be helpful for Buddhists' social analyses. Buddhism for its part offers mimetic theory a centuries-old tradition of reflection on the role of desire in the construction of an illusory self as well as a body of practical wisdom on non-violence that, even if it has not always been put into practice, challenges and instructs the human community today. The popular images of Buddhist peacemakers are, after all, deeply rooted in the early Buddhist tradition and powerfully represented by contemporary figures such as the Dalai Lama, Mahaghosananda (the Patriarch of Cambodian Buddhism and Thich Nhat Hanh (a Vietnamese Zen Buddhist leader who has been nominated for the Nobel Peace Prize). 176Leo D. Lefebure I approach this discussion not as a professional scholar of Buddhism but as a Christian theologian who has been involved in Buddhist-Christian dialogue and who is interested in both Buddhism and mimetic theory, as well as in the relations between these two trajectories today. One model for further discussion would be to take the historical data that Ives has set forth and then apply mimetic theory, asking to what degree mimetic theory can illumine the dynamics and developments of Buddhist history. Using Bernard Lonergan's image of the scissors, which Charles Heflingmentionedin his discussion inthis conference, this approach would cast Buddhism in the role of providing the lower blade of the scissors, the data to be understood, and mimetic theory would provide the upper blade of the scissors, the analytic concepts to understand the data and to make judgments and decisions. In this method, Buddhism would be relatively passive and mimetic theory would be more active. I am sure that there is ample material in Buddhist history that lends itselfto mimetic analysis (one can think ofthe traditional treatment ofthe so-called "outcasts" in Japanese society). One could, as James Alison noted in his opening address, go on endlessly, even obsessively applyingmimetic concepts to different areas of human experience. I am not sure this qualifies as true dialogue, however. It risks continuing the older Orientalist assumption that only Western concepts are capable of understanding Asia's experience and that Asians themselves have relatively little to contribute.1 For a true dialogue, the voices ofboth traditions must play a rather more active role. Both traditions can furnish material for both the upper and the lower blades of the scissors. In Lonergan's terminology, we aremovingbeyondinterpretation, which seeks understanding, and beyond history, which for Lonergan asks what is going forward in history, to the distinct functional specialization of dialectic (Lonergan 125?30). This discipline reflects upon the underlying values at work in historical processes and the assumptions behind these values. In this inquiry we ask about the status of differences of perspective: to what degree are they complementary and where are they contradictory? I would like to organize the discussion between Buddhist perspectives and mimetic theory around the three central points of mimetic theory, which René Girard himself has described as his three most important discoveries: (1) the mimetic construction of desire as the source of human identity, (2) the surrogate victim mechanism as the central dynamic of 1 On Orientalism, see Edward W. Said, Orientalism (New York: Vintage Books, 1979). A Response to Christopher Ives177 primal religion and culture, and (3) biblical revelation as the unique, unparalleled unmasking of the surrogate victim mechanism... (shrink)

Charles W. Curtis is a prominent mathematician who has made important contributions to the field of representation theory. His textbooks in this field have been classics for a long time. In Pioneers of Representation Theory he has set out to present the historical development of the main ideas of the discipline, from the work of Georg Ferdinand Frobenius in the 1890s up to 1960. In addition to Frobenius, the book focuses mainly on three other “pioneers”: William Burnside, Issai Schur, and (...) Richard Brauer.Curtis states that his interest in the history of representation theory arose gradually, and jointly with that of Reiner, in the process of writing their textbooks. Thus, a main aim of the book is to show how the pioneers reached their important results while using only the mathematics then available to them. In order to do so, Curtis presents successive and thorough accounts of the works in which the new and seminal ideas of the pioneers were introduced and then developed. At the same time, however, he simplifies some of the original arguments by translating them into modern terminology.In an attempt to make the book appealing and accessible to a wider circle of potential readers, some of the necessary mathematics is explained. Thus Chapter 1 presents an introduction to the basic ideas and problems of nineteenth‐century algebra and number theory; later on, as the need arises, additional mathematical sections addressed to nonexperts are included. Of course, even this very clear presentation will be accessible only to readers with at least a graduate‐level knowledge of algebra.Curtis also attempts to provide some historical context. He is particularly concerned to clarify the main problems that the work of each of the mathematicians discussed here was originally meant to resolve. In a book of this kind this is surely one of the major benefits that the reader may expect to obtain.There are biographical sketches of the major figures involved, as well as additional information about other participants. Some illuminating documents are quoted, and Curtis supplies brief accounts of the mathematical traditions within which each of the pioneers was educated and worked. He acknowledges, however, that Pioneers of Representation Theory has only a limited claim as a work of historical research. He thus provides references to more historically oriented work that interested readers can consult. In particular, he mentions several articles by Thomas Hawkins; it should be stressed that much of Hawkins's work has recently been published in book form: Emergence of the Theory of Lie Groups: An Essay in the History of Mathematics, 1869–1926 . Curtis's and Hawkins's books complement each other in many important ways, and each should appeal to readers of the other.Charles Curtis has written an impressive, authoritative, and well‐informed book on a difficult subject. Mathematicians and historians of twentieth‐century mathematics with the relevant background will find it difficult but rewarding reading. Along the way, historiographical questions may arise. To what extent is it possible to translate, as Curtis does, the original proofs of the pioneers into more modern terminology and yet remain faithful to the sources? In most cases, however, it will require the technical expertise of the author himself to answer questions like this one properly. We can only hope that the firm starting point this book provides will lead Curtis to further historical research in this and related fields. (shrink)

In this paper, I consider a popular version of the clever student’s reasoning in the surprise examination case, and demonstrate that a valid argument can be constructed. The valid argument is a reductio ad absurdum with the proposition that the student knows on the morning of the first day that the teacher’s announcement is fulfilled as its reductio. But it would not give rise to any paradox. In the process, I criticize Saul Kripke’s solution and Timothy Williamson’s attack on a (...) key step of the student’s reasoning. I then consider the condemned prisoner case in W. V. Quine’s paper ‘On a So-Called Paradox’. I argue that the prisoner’s reasoning as conceived by Quine is more relevant and reasonable than the student’s argument in the popular version of the surprise examination case. I also argue that Quine’s criticism of the prisoner’s reasoning is correct, and therefore that the condemned prisoner case, and the surprise examination case as well, would not generate any paradox. (shrink)

Atypical structural properties of the brain’s white matter bundles have been associated with failing reading acquisition in developmental dyslexia. Because these white matter properties may show dynamic changes with age and orthographic depth, we examined fractional anisotropy (FA) along 16 white matter tracts in 8- to 11-year-old dyslexic (DR) and typically reading (TR) children learning to read in a fairly transparent orthography (Dutch). Our results showed higher FA values in the bilateral anterior thalamic radiations of DRs and FA values of (...) the left thalamic radiation scaled with behavioral reading-related scores. Furthermore, DRs tended to have atypical FA values in the bilateral arcuate fasciculi. Children’s age additionally predicted FA values along the tracts. Together, our findings suggest differential contributions of cortical and thalamo-cortical pathways to the developing reading network in dyslexic and typical readers, possibly indicating prolonged letter-by-letter reading or increased attentional and/or working memory demands in dyslexic children during reading. (shrink)

Cancer and its treatment pose challenges that affect not only patients but also their significant others, including intimate partners. Accumulating evidence suggests that couples’ ability to communicate effectively plays a major role in the psychological adjustment of both individuals and the quality of their relationship. Two key conceptual models have been proposed to account for how couple communication impacts psychological and relationship adjustment: the social-cognitive processing (SCP) model and the relationship intimacy (RI) model. These models posit different mechanisms and outcomes, (...) and thus have different implications for intervention. The purpose of this project is to test and compare the utility of these models using comprehensive and methodologically rigorous methods. Aims are: (1) to examine the overall fit of the SCP and RI models in explaining patient and partner psychological and relationship adjustment as they occur on a day-to-day basis and over the course of 1 year; (2) to examine the fit of the models for different subgroups (males vs. females, and patients vs. partners); and (3) to examine the utility of various methods of assessing communication by examining the degree to which baseline indices from different measurement strategies predict self-reported adjustment at 1-year follow up. The study employs a longitudinal, multi-method approach to examining communication processes including: standard self-report questionnaires assessing process and outcome variables collected quarterly over the course of 1 year; smartphone-based ecological momentary assessments to sample participant reports in real time; and laboratory-based couple conversations from which we derive observational measures of communicative behavior and affective expression, as well as vocal indices of emotional arousal. Participants are patients with stage II-IV breast, colon, rectal, or lung cancer and their spouses/partners, recruited from two NCI-designated comprehensive cancer centers. Results will be published in scientific journals, presented at scientific conferences, and conveyed to a larger audience through infographics and social media outlets. Findings will inform theory, measurement, and the design and implementation of efficacious interventions aimed at optimizing both patient and partner well-being. (shrink)

Este artigo investiga a “Tese” do primado do objeto na obra de Theodor W. Adorno, central ao seu materialismo não dogmático e relativamente pouco estudada. O primado do objeto será apresentado em seus elementos constitutivos, como crítica ao modo essencialmente idealista da dialética que perpassa o conjunto da obra de Adorno, em especial nos textos e discussões que precederam a publicação da Dialektik der Aufklãrung, para se explicitar no período de elaboração da Negative Dialektik. A “Tese” desenvolve momentos apresentados por (...) Lukács, Benjamin e Horkheimer, particularmente quanto ao nexo entre razão e experiência e se fundamenta especialmente no trajeto Kant – Hegel, como crítica ao idealismo, incorporando de modo estruturante as perspectivas de Marx e de Nietzsche. Ao romper a pretensa “simetria” entre sujeito e objeto, a “Tese” do primado do objeto revela como é insustentável a alegação habermasiana do Discurso filosófico da modernidade segundo a qual Adorno e Horkheimer incidiriam num ceticismo total frente à razão e à sua totalização ideológica. Ao contrário: estes autores, ao articularem de um modo original substância material histórica e argumentação teórica, contribuíram de modo fundamental para examinar o problema da reificação mediante sua relação à objetividade – como o não-idêntico – no âmbito da razão. (shrink)